Definition:

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Liposology®Iron Health Benefits:

Liposology®Iron is a complex formed by encapsulating elemental iron (e.g., iron ions or compounds) within the structure of liposomes, which are nanoscale vesicles composed of a phospholipid bilayer. Liposomes act as carriers, encapsulating iron in a stable form that increases its bioavailability and reduces adverse effects. Common compounds that provide iron in the food industry include divalent iron (ferrous glycinate,ferrous sulphate and ferrous fumarate) and trivalent iron (ferric pyrophosphate).

■ Technical characteristics

Improve iron bioavailability: Traditional iron easily combines with acids and proteins in the gastrointestinal tract to form complexes that are difficult to absorb. Liposology®Iron can protect iron ions from the gastrointestinal environment and enter the bloodstream directly through endocytosis, improving absorption efficiency.

Reduce gastrointestinal irritation: Traditional iron supplements can cause nausea, constipation, diarrhea, and other side effects because free iron ions stimulate the gastrointestinal mucosa directly. Liposology®Iron can reduce the degree of freedom of iron ions, thereby reducing stimulation.

Stability and antioxidants: The liposome membrane can isolate iron ions from contact with oxygen and water, preventing iron oxidation and deterioration (e.g., a rusty flavor) and prolonging the product's shelf life.

Particularities of Liposology®Iron:

Product Specifications:

Liposology®Iron is available in the following specification and contents:

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☑ Liposology®Ferrous glycinate powder 70%

Product quality standards:

● In-house, food grade

Ingredients:

●The core component is divalent or trivalent iron compounds, and the carrier material is natural phospholipids(e.g., sunflower lecithin) . These components form a bilayer membrane structure, with the Iron encapsulated within the aqueous core of the liposome.

▶ Efficient iron supplement

▶ Enhanced safety

Liposology®Iron Applications:

Liposology®Iron can be used as a nutritional supplement. It is used to prevent and treat iron deficiency anemia and is commonly taken in the form of tablets, capsules, or an oral solution by pregnant women, children, vegetarians, and others at high risk for iron deficiency. Liposomal iron and vitamin C complex can further promote iron absorption. Liposology®Iron can be added to beverages, dairy products, and cereals as an iron fortifier without affecting the taste or color of the food. Examples include iron-fortified fruit juices and infant formulas.

Liposology®Iron can be used as a cosmetic ingredient in scalp care products to repair the skin barrier and improve dullness. Additionally, liposomal iron can be used to prepare iron supplements, particularly for patients who are intolerant to conventional supplements. Liposology® Iron can improve iron utilization efficiency for anemia caused by chronic kidney disease, tumors, and other conditions.

Liposology®Iron is delivered through liposome targeting, entering the blood circulation directly and rapidly raising the serum iron level. This corrects iron deficiency anemia and improves symptoms such as pallor, dizziness, and fatigue.

Liposology®Iron is slowly released, which irritates the gastric mucosa less and is less likely to cause constipation, nausea, and other side effects. It is suitable for pregnant women, children, and people with sensitive gastrointestinal systems.

▶ Antioxidant

Liposology®Iron reduces oxidative damage in iron-sensitive tissues, such as hepatocytes and cardiomyocytes, by decreasing the fenton reaction triggered by free Fe²⁺.

☑ Liposology®Ferrous fumarate powder 45%

☑ Liposology®Ferric pyrophosphate powder 50%

■ Production technology description

Some common food processing preparation methods are thin film dispersion, reverse evaporation, and high-pressure homogenization. Liposology®Iron is prepared using the thin film dispersion-ultrasonication method, which uses natural phospholipids to form a bilayer membrane that encapsulates the iron compound within the aqueous core of the liposome. Once inside the human body, the liposomes can evade the enzymatic action of the gastrointestinal tract and release the drug via endocytosis or membrane fusion to achieve targeted delivery. This method controls the particle size of the product at the nanometer level. This avoids the first-pass effect in the liver and is especially suitable for pregnant women, patients with iron deficiency anemia, and people who are intolerant to traditional iron supplements.

■ Fe2+ vs. Fe3+

The body primarily absorbs divalent iron. It is absorbed directly by divalent metal ion transport proteins on the mucosal cells of the duodenum and jejunum. Trivalent iron in food must bind to transferrin to form a complex that can be transported in the blood to tissues such as the liver and bone marrow. Since transferrin only recognizes trivalent iron, divalent iron must be absorbed and oxidized to trivalent iron by ferroportin before it can be bound and transported. Oral iron supplements are typically chosen for their high absorption rate of Fe2+ (about 20% to 30%). However, they should be taken with vitamin C to prevent oxidation and should be avoided with antacids, as alkaline environments are prone to Fe2+ precipitation. For individuals with gastrointestinal sensitivities, Fe3+preparations are available. They are highly stable and less irritating; however, care should be taken to ensure they are accompanied by a reducing agent to promote absorption. Different iron supplements are available for different applications and populations.

☑ Liposology®Ferric pyrophosphate powder 80%

▶ Immunomodulatory

Specific lipid components, such as phosphatidylserine, modulate macrophage polarization and reduce the release of inflammatory factors, such as TNF-α and IL-6. This makes them suitable for iron-deficient patients with co-infections or inflammation, as conventional iron may exacerbate inflammation.