◣

◢

Vitamin K is essential for the liver to synthesize clotting factors II (prothrombin), VII, IX, and X. These clotting factors play a key role in blood clotting, helping to stop bleeding and heal wounds.

Nutrivitas®Vitamin K Health Benefits:

■ Source

In 1935, Dahm announced the discovery of a new vitamin, which he called the "blood clotting vitamin," vitamin K. The best sources of vitamin K are leafy greens, tomatoes, and pork liver. In 1939, Dahm purified fat-soluble vitamin K from alfalfa. Vitamin K isolated from green plants is called K1, while vitamin K produced by the rancid action of the colon is called K2. In 1940, Doisy was the first to synthesize vitamin K and determine its chemical formula. Dahm and Doisy were jointly awarded the Nobel Prize in Physiology or Medicine in 1943.

Nutrivitas®Vitamin K1 from natural plant sources is used primarily for its anticoagulant properties, and Nutrivitas®Vitamin K2 produced in the gut is used primarily in dietary supplements for a variety of functions.

■ Absorption and metabolism

Dietary intake of vitamin K, mainly vitamin K1, vitamin K2 is mainly synthesized by intestinal flora. Vitamin K is absorbed with lipids in the intestinal lymphatic system, 40-70% of the intake can be absorbed through the bile with fecal excretion, partially eliminated through the urine of anaerobic bacteria in the large intestine can be synthesized vitamin K.

■ Fermentation vs. Synthetic

There are two main sources of vitamin K2: chemical synthesis method and fermentation method. Fermentation method to produce vitamin K2 is mainly based on natto bacterial fermentation; vitamin K2 (synthetic method) to produce vitamin K, farnesol and geraniol as 3 raw materials, synthesized to produce food fortification vitamins.Vitamin K2 produced by the synthetic method has an all-trans fraction of less than 50%, whereas vitamin K2 produced by the fermentation method has an all-trans fraction of more than 99%.

Physical and Chemical Properties:

Production technology description:

● Nutrivitas®Vitamin K1 can be produced through chemical synthesis using naphthoquinone as the starting material. This process involves methylation, alkylation, and other reactions.

▶ Promotes blood clotting

▶ Bone health

▶ Boost immunity

▶ Cardiovascular health

▶ Maintenance of cellular function

▶ Food field

▶ Pharmaceutical field

Nutrivitas®Vitamin K is available in a variety of pharmaceutical dosage forms, including vitamin K tablets, vitamin K injections, and vitamin K oral preparations. Vitamin K is used primarily for the treatment of obstructive jaundice due to various causes, chronic ulcerative colitis, chronic pancreatitis, and reduced intestinal absorption after extensive small bowel resection, as well as for vitamin K deficiency in the body due to long-term antibiotic use.

▶ Cosmetics field

The main dosage forms of vitamin K in cosmetics are creams and eye patches. The main roles of vitamin K in cosmetics include antioxidant, dark circles removal and skin elasticity improvement.

Nutrivitas®Vitamin K Applications:

Nutrivitas®Vitamin K is widely used in the field of nutritional fortification of daily food, it can be used in health food (auxiliary calcium, auxiliary prevention and treatment of osteoporosis, etc.); dietary supplements, food (auxiliary calcium, etc.); beverages (sports drinks, auxiliary improvement of muscle cramps, etc.).

Particularities of Nutrivitas®Vitamin K:

Product Specifications:

Nutrivitas®Vitamin K is available in the following specification and contents:

○

○

☑  Nutrivitas®Vitamin K1 oil 97% Min, vegan
☑ Nutrivitas®Vitamin K2 (MK-7) pure 96%-101%

☑ Nutrivitas®Vitamin K2 (MK-7) oil 1500/5000/10000ppm Min, vegan,customized
☑ Nutrivitas®Vitamin K2 (MK-4) pure 98%, vegan

☑ Nutrivitas®Vitamin K2 (MK-4) oil 1500ppm Min, customized

☑ Nutrivitas®Vitamin K2 (MK-9) pure 98%, vegan
☑ Nutrivitas®Vitamin K3-MSB 96%, feed grade

☑ Nutrivitas®Vitamin K3-MNB 96%, feed grade

☑  Nutrivitas®Vitamin K3-MSBC 65%, feed grade

Vitamin K is involved in bone metabolism in the body and helps promote bone growth and density. It has a beneficial effect on the uncomfortable symptoms caused by osteoporosis.

Vitamin K also plays an important role in cell function and immune response, which can enhance human immunity, and proper supplementation can improve the ability to resist disease.

Vitamin K may also play a role in cardiovascular health by inhibiting the calcification process in blood vessels and maintaining their elasticity and normal function.

Vitamin K is involved in maintaining normal cellular function and regulating gene expression, and plays a regulatory role in the function of organs and tissues such as the liver, kidneys, and immune system.

■ MK-4 vs. MK-7

Vitamin K2 (Menaquinone) comes in a variety of structural forms, the most common of which are synthetic MK-4 and natural MK-7. MK-7 has an all-trans structure with a linear molecule, lower energy, and higher bioavailability and biological effects. In contrast, MK-4 is an all-cis structure with a curved molecule, higher energy, and lower bioavailability and biological effects.

Vitamin K2 (MK-7) is mainly found in natto and vitamin K2 (MK-4) is mainly found in meat. Vitamin K2 is mainly produced by fermentation and synthesis. Chemically synthesized vitamin K2 is mainly MK-4, while MK-7 is mainly found in natural ferments. Vitamin K2 (MK-7) is mainly used for osteoporosis, atherosclerosis, Parkinson's disease, and also reduces the risk of cardiovascular and brain disorders. Vitamin K2 (MK-4) is mainly used in osteoporosis. MK-4 has a half-life of one hour in the body, while MK-7 has a half-life of three days. MK-4, a synthetic form of vitamin K2, cannot maintain therapeutic levels in the bloodstream for long periods of time. However, MK-7 can effectively remain in the bloodstream for much longer.

● Nutrivitas®Vitamin K2 is produced by fermentation method, after separation and purification, crystallization, drying, filtration and other processes to form a pure product, and then use a variety of carrier oils for dilution and adjustment into different specifications of oil products.

BP, EP, USP, In-house, Feed grade

Product quality standards: